The present study aims to identify the connectivity of the seizure onset zone (SOZ) in patients with MRI-negative epilepsy. Motivated by recent findings of aberrant white matter structure in epilepsy we hypothesized differences in structural connectivity. To test this we compared structural connectivity in a group of 8 epilepsy subjects and 8 healthy controls. We also investigated differences in connectivity in SOZ and non-SOZ areas in the epilepsy group. Hyper-connectivity was found in epilepsy subjects compared to controls. Additionally, hyper-connectivity was found in SOZ compared to non-SOZ related regions. These findings may have implications for diagnosis and surgical intervention in MRI-negative epilepsy.
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