Meeting Banner
Abstract #3484

Hyper-connectivity of the Seizure Onset Zone: A Potential Epilepsy Biomarker at 7T

Jack Rutland 1,2, Rebecca Feldman1, Lara Marcuse 3, Madeline Fields 3, Bradley Delman 1, Priti Balchandani1, and Rafael O'Halloran1

1Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Wake Forest University, Winston-Salem, NC, United States, 3Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

The present study aims to identify the connectivity of the seizure onset zone (SOZ) in patients with MRI-negative epilepsy. Motivated by recent findings of aberrant white matter structure in epilepsy we hypothesized differences in structural connectivity. To test this we compared structural connectivity in a group of 8 epilepsy subjects and 8 healthy controls. We also investigated differences in connectivity in SOZ and non-SOZ areas in the epilepsy group. Hyper-connectivity was found in epilepsy subjects compared to controls. Additionally, hyper-connectivity was found in SOZ compared to non-SOZ related regions. These findings may have implications for diagnosis and surgical intervention in MRI-negative epilepsy.

This abstract and the presentation materials are available to members only; a login is required.

Join Here