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Abstract #3485

High-Throughput Diffusion Imaging Using Multiple Coils for Mouse Brain Connectomics

John Nouls1,2, Alexandra Badea1,2, Robert J. Anderson1,2, Gary P. Cofer1,2, and G. Allan Johnson1,2

1Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, United States, 2Radiology, Duke University Medical Center, Durham, NC, United States

The complex neural architecture and brain connectivity of mouse models of human disease can be studied ex vivo by diffusion tensor imaging; however, acquisition times are long and make cohort studies prohibitively time-consuming. Throughput can be increased by the simultaneous use of multiple coils placed in proximity to the magnet isocenter. We quantify the impact of the multiple-coil configuration on throughput, on diffusion metrics used in tractography, and on mouse brain connectivity matrices. We show that fractional anisotropy is underestimated off-isocenter, while the main eigenvector direction is minimally affected. The effect on brain connectivity networks is currently being quantified.

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