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Abstract #3486

Prediction vision recovery of Neuromyelitis optica spectrum disorders (NMOSDs) with multivariate pattern analysis: a DTI study

Yuan Tian1, Lin Ma1, Zhenyu Liu2, Zhenchao Tang3, Xin Lou, Jie Tian, and Mingge Li

1radiology department, Chinese PLA General Hospital, beijing, People's Republic of China, 2Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, 3School of Mechanical, Electrical & Information Engineering, Shandong University

To explore if a DTI protocol could provide a model to predict the degree of vision recovery in NMOSDs patients. 37 patients were employed in the study, including 20 patients of well vision recovery and 17 patients of poor vision recovery. With the diffusion measure of multiple white and grey matters as features, a Lasso-Logistic regression model and a Support Vector Machine (SVM)-based classification model were constructed. The results show area under curve (AUC) of 0.7618 (P=0.008) and accuracy (ACC) of 0.7297 (0.006). The method shows promising prediction performance, and it has the potential to improve the clinical treatment design.

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