The anatomical definition and functional role of inferior fronto-occipital fascicle (IFOF) in human brain are important but still controversial. Post-mortem dissection has provided detailed and extended cortical terminations of IFOF while diffusion tractography further facilitates the definition of extended terminations through in vivo studies. A careful comparison of fiber reconstruction methods including diffusion tensor imaging, q-ball imaging, generalized q-sampling imaging and diffusion kurtosis imaging (DKI) was conducted. More integrated IFOF tracts were found with DKI, which could benefit the exploration of precise terminations of IFOF, thus a better understanding of its function.
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