Abstract #3496

Comparison of rotenone-induced rat model and 6-OHDA-induced rat model of Parkinson's disease: FA and T2* values analysis

LanXiang Liu¹, Dan Du¹, Tao Zheng², Yuan Fang¹, Yansheng Chen¹, Huiling Yi¹, Qingyuan He³, Dawei Gao⁴, and Qinglei Shi⁵

¹Qinhuangdao Municipal No. 1 Hospital, Hebei, People's Republic of China, ²Hebei Medical University, Shijia Zhuang, Hebei, People's Republic of China, ³Peking University Third Hospital, ⁴Yanshan Universiry, ⁵Siemens Ltd

The fractional anisotropy (FA) and T2* values of rotenone (RT) and 6-OHDA-induced rat model of PD at different time points were quantitatively analyzed. A larger degree of quantitative parameters variation in 6-OHDA-induced rat group than RT-induced rat group were demonstrated when using quantitative parameters of FA and T2* values. The phenomena observed in this study may be of help in future studies about PD using rat model.

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