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Abstract #3496

Comparison of rotenone-induced rat model and 6-OHDA-induced rat model of Parkinson's disease: FA and T2* values analysis

LanXiang Liu1, Dan Du1, Tao Zheng2, Yuan Fang1, Yansheng Chen1, Huiling Yi1, Qingyuan He3, Dawei Gao4, and Qinglei Shi5

1Qinhuangdao Municipal No. 1 Hospital, Hebei, People's Republic of China, 2Hebei Medical University, Shijia Zhuang, Hebei, People's Republic of China, 3Peking University Third Hospital, 4Yanshan Universiry, 5Siemens Ltd

The fractional anisotropy (FA) and T2* values of rotenone (RT) and 6-OHDA-induced rat model of PD at different time points were quantitatively analyzed. A larger degree of quantitative parameters variation in 6-OHDA-induced rat group than RT-induced rat group were demonstrated when using quantitative parameters of FA and T2* values. The phenomena observed in this study may be of help in future studies about PD using rat model.

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