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Abstract #3504

Compressed sensing diffusion spectrum imaging as a forward-looking alternative to multi-shell diffusion MRI in population imaging

Alexandra Tobisch1, Rüdiger Stirnberg1, Robbert Leonard Harms2, Thomas Schultz3, Alard Roebroeck2, Monique Breteler1, and Tony Stöcker1

1German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 2Faculty of Psychology & Neuroscience, Maastricht University, Maastricht, Netherlands, 3University of Bonn, Institute of Computer Science, Bonn, Germany

This study investigates the applicability of two advanced diffusion MRI protocols in population imaging: 3-shell High Angular Resolution Diffusion Imaging (HARDI) and Diffusion Spectrum Imaging accelerated through Compressed Sensing theory (CS-DSI). Group analysis of 20 subjects indicates that CS-DSI performs comparable to 3-shell HARDI in the estimation of microstructure parameters and adds the advantage of high b-value acquisitions, further complimentary biomarkers from the diffusion propagator and a high potential to deliver data well-suited for future developments.

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