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Abstract #3507

High b-value Diffusion-Weighted MRI for Detection of Interscapular Brown Adipose Tissue in Rodent Model

Weiguo Li1,2,3, Jin Gao3, Andrew Gordon2, Kejia Cai4, Andrew Larson2, and Richard Magin3

1Research Resource Center, University of Illinois at Chicago, Chicago, IL, United States, 2Radiology, Northwestern University, Chicago, IL, United States, 3Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, 4Radiology, University of Illinois at Chicago, Chicago, IL, United States

Brown adipose tissue (BAT) is increasingly considered a target organ for the treatment of metabolic disease. Persuasive evidence has shown that enhance­ment of the function of brown and beige adipocytes in humans could be very effective for treating type 2 diabetes and obesity. However, clinical studies have been limited by the lack of non-invasive tools for characterizing this tissue in humans. In this study, we explored the feasibility of using high b-value diffusion-weighted MRI for detecting the distribution of interscapular brown adipose tissue.

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