Abstract #3508

Free-water elimination in diffusion MRI: pushing the limits towards clinical applications

Ezequiel Farrher¹, Farida Grinberg^1,2, Zaheer Abbas^1,2, and N. Jon Shah^1,2,3

¹Institute of Neuroscience and Medicine 4, Forschungszentrum Jülich, Jülich, Germany, ²Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, ³JARA – BRAIN – Translational Medicine, RWTH Aachen University, Aachen, Germany

Free-water elimination allows one to reduce the bias in DTI metrics induced by partial-volume effects. In this work, we propose a versatile approach for the optimisation of the diffusion weighting settings, given a limited acquisition time, based on a parameterised Cramér-Rao lower-bound. The optimisation shows robust convergence.

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