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Abstract #3508

Free-water elimination in diffusion MRI: pushing the limits towards clinical applications

Ezequiel Farrher1, Farida Grinberg1,2, Zaheer Abbas1,2, and N. Jon Shah1,2,3

1Institute of Neuroscience and Medicine 4, Forschungszentrum Jülich, Jülich, Germany, 2Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, 3JARA – BRAIN – Translational Medicine, RWTH Aachen University, Aachen, Germany

Free-water elimination allows one to reduce the bias in DTI metrics induced by partial-volume effects. In this work, we propose a versatile approach for the optimisation of the diffusion weighting settings, given a limited acquisition time, based on a parameterised Cramér-Rao lower-bound. The optimisation shows robust convergence.

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