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Abstract #3509

Assessing the Effect of Intravoxel Incoherent Motion on Diffusion Parameters in the Brain

Casey Robert Vieni1,2, Benjamin Ades-Aron1, Bettina Conti1, Timothy M Shepherd1, Yvonne W Lui1, Dmitry Novikov1, and Els Fieremans1

1Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York University, New York, NY, United States, 2Medical Scientist Training Program, New York University School of Medicine, New York, NY, United States

We investigated the effect of intravoxel incoherent motion (IVIM) on the brain diffusion MRI signal in a cohort of 143 control patients. We compared the diffusivities derived from a mono-exponential fit at b =0 and 1ms/μm2 versus at b = 0.25 and 1 ms/μm2. This allowed for a quantitative assessment of the IVIM signal fraction f* in specific brain matter types. Our results show a significant difference in the mean diffusivity of about 3% in white matter and up to 7% in grey matter, with corresponding f* estimated to be about 2% and 6% in white and grey matter respectively.

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