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Abstract #3545

Hyperpolarized [1-13C]pyruvate reveals increase of hepatic LDH activity following a glucose challenge in pigs

Uffe Kjærgaard1, Christoffer Laustsen1, Thomas Nørlinger1, Emmeli Mikkelsen1, Rasmus Stilling Tougaard2, Qi Haiyun1, Lotte Bonde Bertelsen1, Niels Jessen3, and Hans Stødkilde-Jørgensen1

1MR Research Centre, Aarhus University Hospital, Aarhus, DK, Aarhus N, Denmark, 2Department of Cardiology – Research, Aarhus University Hospital, Aarhus, DK, 3Department of Clinical Medicine - Research Laboratory for Biochemical Pathology, Aarhus University, Aarhus, DK

Hepatic regulation of glucose homeostasis is of pivotal importance and thus in vivo interrogation of hepatic energetic alterations in disease and treatment non-invasively using [1-13C] pyruvate has been proposed as a novel modality for assessing metabolic status. Here we investigated the metabolic effect of a glucose challenge on the porcine liver. A hepatic metabolic shift towards a reduced gluconeogenesis (increased lactate pool size) was observed following the glucose challenge, confirming hyperpolarized 13C MR’s ability to detect such changes. These findings support the use of hyperpolarized MR in metabolic challenge test in patients.

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