Hepatic regulation of glucose homeostasis is of pivotal importance and thus in vivo interrogation of hepatic energetic alterations in disease and treatment non-invasively using [1-13C] pyruvate has been proposed as a novel modality for assessing metabolic status. Here we investigated the metabolic effect of a glucose challenge on the porcine liver. A hepatic metabolic shift towards a reduced gluconeogenesis (increased lactate pool size) was observed following the glucose challenge, confirming hyperpolarized 13C MR’s ability to detect such changes. These findings support the use of hyperpolarized MR in metabolic challenge test in patients.
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