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Abstract #3546

4D-MRI with 3D radial sampling and self-gating-based K-space sorting: image quality improvement by slab-selective excitation

Zixin Deng1,2, Wensha Yang3, Jianing Pang1,4, Richard Tuli3, Behrooz Hakimian3, Robert Reznik3, Xiaoming Bi5, Benedick Fraass3, Debiao Li1,2,6, and Zhaoyang Fan1

1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3Radiation Oncology, Cedars-Sinai Medical Center, 4Siemens Healthcare R&D, Chicago, IL, United States, 5Siemens Healthcare R&D, Los Angeles, CA, United States, 6Medicine, University of California, Los Angeles, Los Angeles, United States

Stereotactic body radiation therapy with a simultaneous integrated boost (SBRT-SIB) has been used to improve tumor resection rate by sterilizing cancerous tissue that are surrounding the vessels. Accurate tumor imaging and tumor motion assessment will enhance the potential for SBRT-SIB. 4D-MRI (respiratory resolved, 3D volumetric images) has emerged as a promising imaging technique for characterizing tumor motion due to the absence of ionizing radiation and its superior soft tissue contrast. This study explored a slab-selective excitation approach to increase the blood vessel to tissue contrast with the goal of improving the accuracy of boost volume definition in radiation therapy.

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