Abstract #3547

PET/MR in pancreatic cancer: correlation between overall survival and functional imaging biomarkers from DCE-MRI, DWI, MR spectroscopy and PET

Bang-Bin Chen¹, Yu-Wen Tien², Ming-Chu Chang³, Mei-Fang Cheng⁴, Shih-Hung Yang⁵, and Tiffany Ting-Fang Shih^6,7

¹Department of Medical Imaging and Radiology, National Taiwan University Medical School and Hospital, Taipei, Taiwan, ²Department of Surgery, National Taiwan University Medical School and Hospital, ³Department of Internal Medicine, National Taiwan University Medical School and Hospital, ⁴Department of Nuclear Medicine, National Taiwan University Medical School and Hospital, ⁵Department of Oncology, National Taiwan University Medical School and Hospital, ⁶Departmen of Radiology, National Taiwan University Medical School and Hospital, Taipei, Taiwan, ⁷Department of Medial Imaging, Taipei City Hospital

The purpose of this study is to evaluate the association of imaging biomarkers from PET/MR with overall survival in pancreatic cancer patients. Sixty-four patients with pathologically-proven pancreatic adenocarcinoma underwent PET/MRI before treatment. The imaging biomarkers included Ktrans and Peak from DCE-MRI, minimal apparent diffusion coefficient from DWI, choline from MR spectroscopy, standard uptake values, metabolic tumor volume, and total lesion glycolysis of the tumors. Among all imaging parameters, Peak was found to be an independent predictor for overall survival in these patients. Thus, the imaging biomarkers from PET/MRI reflect different tumor characteristics and may predict survival outcome in these patients.

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