The purpose of this study is to evaluate the association of imaging biomarkers from PET/MR with overall survival in pancreatic cancer patients. Sixty-four patients with pathologically-proven pancreatic adenocarcinoma underwent PET/MRI before treatment. The imaging biomarkers included Ktrans and Peak from DCE-MRI, minimal apparent diffusion coefficient from DWI, choline from MR spectroscopy, standard uptake values, metabolic tumor volume, and total lesion glycolysis of the tumors. Among all imaging parameters, Peak was found to be an independent predictor for overall survival in these patients. Thus, the imaging biomarkers from PET/MRI reflect different tumor characteristics and may predict survival outcome in these patients.