Abstract #3548

T1- MRI Assessment of Hepatobiliary Fibrosis in Cystic Fibrosis Patients: Significance for Chronic Liver Diseases

Shannon Donnola¹, Kimberly McBennett^2,3, David Weaver³, Lan Lu^1,4, Xin Yu^1,5,6, James Chmiel³, Michael Konstan³, Mitchell Drumm^3,7, and Chris Flask^1,3,5

¹Radiology, Case Western Reserve University, Cleveland, OH, United States, ²Medicine, University Hospitals of Cleveland, OH, United States, ³Pediatrics, University Hospitals of Cleveland, Cleveland, OH, United States, ⁴Urology, Case Western Reserve University, Cleveland, OH, United States, ⁵Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ⁶Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States, ⁷Genetics, Case Western Reserve University, Cleveland, OH, United States

Liver disease is the third leading cause of death in Cystic Fibrosis (CF). Unfortunately, conventional liver function tests cannot sensitively detect it.^1-3Liver stiffness measurements via MRI and ultrasound have shown promise but are unfortunately impacted by other factors (e.g., hepatic fat) potentially resulting in over-estimation of fibrosis.^4,5 We recently validated a T1-MRI assessment of biliary dilatation and fibrosis in a rat model of congenital hepatic fibrosis (Figs. 1-3).⁶ In this clinical study, we show that T1-MRI can be used to sensitively detect increased percent bile duct volumes in CF patients in comparison to control subjects with normal liver function.

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