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Abstract #3556

Hepatocyte Fraction: Correlation with non-invasive liver functional biomarkers

Yoshifumi Noda1, Satoshi Goshima1, Tomoyuki Okuaki2, Kimihiro Kajta1, Hiroshi Kawada1, Nobuyuki Kawai1, Hiromi Koyasu1, and Masayuki Matsuo1

1Department of Radiology, Gifu University, Gifu, Japan, 2Philips Healthcare, Tokyo, Japan

The hepatocyte fraction (HeF) is based on simple pharmacokinetics and can quantitatively estimate the fraction of hepatocyte. In our study, the HeF, quantitative liver-to-spleen contrast ratio (Q-LSC), and delta T1 value were compared and correlated with Child-Pugh and MELD score. The HeF demonstrated the highest correlations with Child-Pugh score (r = -0.58, P < 0.0001) and MELD score (r = -0.57, P < 0.0001). The HeF could be a useful biomarker for the evaluation of liver function, compared to conventional imaging based quantitative methods.

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