Meeting Banner
Abstract #3557

Cardiac-induced liver deformation as a measure of liver stiffness: normal volunteer reproducibility and post-prandial stress studies

Manil Chouhan1, Alex Menys1, Alan Bainbridge2, David Atkinson1, Shonit Punwani1, Rajeshwar Mookerjee3, and Stuart Taylor1

1UCL Centre for Medical Imaging, University College London, London, United Kingdom, 2Department of Medical Physicist, University College London Hospitals NHS Trust, London, United Kingdom, 3UCL Institute for Liver and Digestive Health, University College London, London, United Kingdom

Liver stiffness measured with elastography has useful clinical applications but requires the use of expensive, specialist equipment. In this study, we acquire dynamic ‘cine’ data of the liver to capture cardiac-induced liver motion during cardiac cine MRI. We quantify these data by applying a registration algorithm and use the deformation fields as a surrogate for liver stiffness. We demonstrate feasibility and good seven-day reproducibility and evaluate the effects of physiological haemodynamic changes using a liquid meal challenge. This technique would be widely applicable to hospital MRI scanners without elastography equipment.

This abstract and the presentation materials are available to members only; a login is required.

Join Here