Abstract #3558

Investigation of liver cirrhosis using 31P-MRS at 7T

Lucian A. B. Purvis¹, William T. Clarke¹, Ladislav Valkovic¹, Christina Levick¹, Michael Pavlides², Eleanor Barnes², Jeremy F. Cobbold², Stefan Neubauer¹, Matthew D. Robson¹, and Christopher T. Rodgers¹

¹OCMR, Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, ²Translational Gastroenterology Unit, University of Oxford, Oxford, United Kingdom

Phosphorus (³¹P) metabolites have potential value as markers in liver disease. The increase in field strength from 3 to 7T allows more accurate quantitation of the liver ³¹P-MRS spectrum. Ten volunteers and eleven patients with liver cirrhosis were scanned using a 16-channel array and a 3D UTE-CSI sequence. Metabolite concentrations were calculated using an endogenous 2.5mM ATP reference. Significant reductions in inorganic phosphate and phosphoenolpyruvate/phosphatidylcholine concentrations were seen, as well as an increase in glycerophosphoethanolamine (P<0.05). The splitting of PDE into its constituent peaks allows more insight into changes in metabolism.

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