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Abstract #3558

Investigation of liver cirrhosis using 31P-MRS at 7T

Lucian A. B. Purvis1, William T. Clarke1, Ladislav Valkovic1, Christina Levick1, Michael Pavlides2, Eleanor Barnes2, Jeremy F. Cobbold2, Stefan Neubauer1, Matthew D. Robson1, and Christopher T. Rodgers1

1OCMR, Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, 2Translational Gastroenterology Unit, University of Oxford, Oxford, United Kingdom

Phosphorus (31P) metabolites have potential value as markers in liver disease. The increase in field strength from 3 to 7T allows more accurate quantitation of the liver 31P-MRS spectrum. Ten volunteers and eleven patients with liver cirrhosis were scanned using a 16-channel array and a 3D UTE-CSI sequence. Metabolite concentrations were calculated using an endogenous 2.5mM ATP reference. Significant reductions in inorganic phosphate and phosphoenolpyruvate/phosphatidylcholine concentrations were seen, as well as an increase in glycerophosphoethanolamine (P<0.05). The splitting of PDE into its constituent peaks allows more insight into changes in metabolism.

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