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Abstract #3574

CEST MRI using sugar alcohol, maltitol, to detect cancer: Study on rat glioma model

Puneet Bagga1, Mohammad Haris2, Kevin D'Aquilla1, Francesco Marincola2, Hari Hariharan1, Ravinder Reddy1, and Puneet Bagga3

1Department of Rediology, University of Pennsylvania, Philadelphia, PA, United States, 2Research Branch, Sidra Medical and Research Center, Doha, Qatar, 3Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

We show the use of a sugar alcohol sweetener, maltitol, in cancer MRI studies by exploiting its chemical exchange saturation transfer (malCEST) property. The tumor specific accumulation of maltitol in a rat glioma model provides localized, temporal changes in the CEST contrast, which corroborated the gadolinium-enhanced MRI. These findings illustrate the potential application of maltitol in the diagnosis and monitoring of the therapeutic response of cancers, including gliomas in preclinical studies.

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