Abstract #3574

CEST MRI using sugar alcohol, maltitol, to detect cancer: Study on rat glioma model

Puneet Bagga¹, Mohammad Haris², Kevin D'Aquilla¹, Francesco Marincola², Hari Hariharan¹, Ravinder Reddy¹, and Puneet Bagga³

¹Department of Rediology, University of Pennsylvania, Philadelphia, PA, United States, ²Research Branch, Sidra Medical and Research Center, Doha, Qatar, ³Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

We show the use of a sugar alcohol sweetener, maltitol, in cancer MRI studies by exploiting its chemical exchange saturation transfer (malCEST) property. The tumor specific accumulation of maltitol in a rat glioma model provides localized, temporal changes in the CEST contrast, which corroborated the gadolinium-enhanced MRI. These findings illustrate the potential application of maltitol in the diagnosis and monitoring of the therapeutic response of cancers, including gliomas in preclinical studies.

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