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Abstract #3573

A novel multimodal mannan-based polymer system suitable for tumor and metastasis diagnosis

Andrea Galisova1, Marketa Jiratova1, Maria Rabyk2, Martin Hruby2, Milan Hajek1, and Daniel Jirak1

1MR Unit, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 2Institute of Macromolecular Chemistry, Prague, Czech Republic

Presented mannan-based polymers have promising properties for tumor and metastasis imaging due to their biocompatibility, nanosize and specificity for the immune cells. In this study, two mannan-based polymers were tested by multimodal imaging (MRI and fluorescence). The polymers showed superior imaging properties compared to a commercially available contrast agent. The polymer modified with oxazoline expressed slower elimination rate from the body. Both probes were visualized by MR and optical imaging modality at the injection sites and in the lymph nodes of the experimental mice suggesting their promising properties for cancer diagnosis.

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