Abstract #3572

Direct hyperpolarization of micro- and nanodiamonds for bioimaging applications – considerations on particle size, functionalization and polarization loss

Grzegorz Kwiatkowski¹, Jonas Steinhauser¹, Patrick Wespi¹, Matthias Ernst², and Sebastian Kozerke¹

¹Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland, ²Physical Chemistry, ETH Zurich, Zurich, Switzerland

Due to the inherently long relaxation time of ¹³C spins in diamonds, the nuclear polarization enhancement obtained with dynamic nuclear polarization can be preserved for a time on the order of ~1h, opening up a window for a new class of long-lived contrast agents. Up to now, no imaging with hyperpolarized micro and nanodiamonds has been reported. The present communication presents the feasibility of applying directly hyperpolarized diamonds in MR imaging including considerations for potential in-vivo applications.

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