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Abstract #3572

Direct hyperpolarization of micro- and nanodiamonds for bioimaging applications – considerations on particle size, functionalization and polarization loss

Grzegorz Kwiatkowski1, Jonas Steinhauser1, Patrick Wespi1, Matthias Ernst2, and Sebastian Kozerke1

1Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland, 2Physical Chemistry, ETH Zurich, Zurich, Switzerland

Due to the inherently long relaxation time of 13C spins in diamonds, the nuclear polarization enhancement obtained with dynamic nuclear polarization can be preserved for a time on the order of ~1h, opening up a window for a new class of long-lived contrast agents. Up to now, no imaging with hyperpolarized micro and nanodiamonds has been reported. The present communication presents the feasibility of applying directly hyperpolarized diamonds in MR imaging including considerations for potential in-vivo applications.

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