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Abstract #3577

Prospective longitudinal evaluation of patients with low-grade cartilage injury using gagCEST at 7T

Markus Schreiner1,2, Vladimir Mlynarik1,3, Didier Laurent4, Vladimir Juras1, Pavol Szomolanyi1, Stefan Zbyn1,5, Celeste Scotti4, Joerg Goldhahn4, Harry Haber4, Ewa Kubiak4, Ronenn Roubenoff4, Stefan Marlovits6, Reinhard Windhager2, and Siegfried Trattnig1,3

1High Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 2Department of Orthopaedics, Medical University of Vienna, Vienna, Austria, 3Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 4Novartis Institutes for Biomedical Research, Basel, Switzerland, 5Research Unit of Medical Imaging, Physics and Technology, University of Oulu and Oulu University Hospital, Oulu, Finland, 6Depatment of Traumatology, Medical University of Vienna, Vienna, Austria

To the best of our knowledge, this is the first study that employs gagCEST for the longitudinal evaluation of untreated articular cartilage defects. We demonstrate that gagCEST at 7T has the potential of discriminating between cartilage defects, weight bearing and non-weight bearing femoral cartilage and therefore might serve as a biomarker for the evaluation of novel cartilage therapies. Furthermore, our study implies that proper fixation of the examined knee may help to increase the reliability of gagCEST experiments.

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