Abstract #3578

Lipo2-DG-CEST: a new theranostic agent for simultaneous tumour imaging and chemotherapy

Eleni Demetriou¹, Harriet Story², Robin Bofinger², Karin Shmueli³, Helen Hailes², Alethea Tabor², and Xavier Golay¹

¹Brain Repair and Rehabilitation, Institute of Neurology, London, United Kingdom, ²Department of Chemistry, University College of London, London, United Kingdom, ³Department of Medical Physics & Bioengineering, University College of London, London, United Kingdom

2-DG has been shown to inhibit tumor growth in vivo; however, it cannot be used as a therapeutic agent in humans due to its toxicity. Here we show the potential for 2-DG-loaded liposomes to provide detectable Chemical Exchange Saturation Transfer (CEST) contrast, and thereby achieve simultaneous tumour imaging and chemotherapy by targeting areas of greater tumour metabolism. The CEST signal arising from 2-DG was compared to liposome-encapsulated 2-DG and to natural D-glucose, respectively. The results demonstrated an increase in signal for2-DG loaded liposomes when compared to both free 2-DG and glucose possibly due to a decrease in the global exchange rate.

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