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Abstract #3578

Lipo2-DG-CEST: a new theranostic agent for simultaneous tumour imaging and chemotherapy

Eleni Demetriou1, Harriet Story2, Robin Bofinger2, Karin Shmueli3, Helen Hailes2, Alethea Tabor2, and Xavier Golay1

1Brain Repair and Rehabilitation, Institute of Neurology, London, United Kingdom, 2Department of Chemistry, University College of London, London, United Kingdom, 3Department of Medical Physics & Bioengineering, University College of London, London, United Kingdom

2-DG has been shown to inhibit tumor growth in vivo; however, it cannot be used as a therapeutic agent in humans due to its toxicity. Here we show the potential for 2-DG-loaded liposomes to provide detectable Chemical Exchange Saturation Transfer (CEST) contrast, and thereby achieve simultaneous tumour imaging and chemotherapy by targeting areas of greater tumour metabolism. The CEST signal arising from 2-DG was compared to liposome-encapsulated 2-DG and to natural D-glucose, respectively. The results demonstrated an increase in signal for2-DG loaded liposomes when compared to both free 2-DG and glucose possibly due to a decrease in the global exchange rate.

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