Abstract #3579

PRO-QUEST: A fast method for exchange rate quantification based on PROgressive saturation for Quantifying Exchange using Saturation Times in Chemical Exchange Saturation Transfer (CEST)

Eleni Demetriou¹, Mohamed Tachrount¹, Karin Shmueli², and Xavier Golay¹

¹Brain Repair and Rehabilitation, Institute of Neurology, London, United Kingdom, ²Department of Medical Physics & Bioengineering, University College of London, London, United Kingdom

In this work we propose a novel pulse sequence for measuring chemical exchange rates through a progressive saturation recovery process PRO-QUEST (PROgressive saturation for Quantifying Exchange using Saturation Times). The water magnetization is sampled under non-steady state conditions and saturation is interleaved with the acquisition of images obtained in a single scan. Unlike previous approaches, it provides maps of T₁ and B₁ , needed for exchange-rate calculations, from the same dataset. The proposed pulse sequence has been successfully applied to obtain exchange rate maps in phantoms and healthy rat brains.

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