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Abstract #3579

PRO-QUEST: A fast method for exchange rate quantification based on PROgressive saturation for Quantifying Exchange using Saturation Times in Chemical Exchange Saturation Transfer (CEST)

Eleni Demetriou1, Mohamed Tachrount1, Karin Shmueli2, and Xavier Golay1

1Brain Repair and Rehabilitation, Institute of Neurology, London, United Kingdom, 2Department of Medical Physics & Bioengineering, University College of London, London, United Kingdom

In this work we propose a novel pulse sequence for measuring chemical exchange rates through a progressive saturation recovery process PRO-QUEST (PROgressive saturation for Quantifying Exchange using Saturation Times). The water magnetization is sampled under non-steady state conditions and saturation is interleaved with the acquisition of images obtained in a single scan. Unlike previous approaches, it provides maps of T1 and B1 , needed for exchange-rate calculations, from the same dataset. The proposed pulse sequence has been successfully applied to obtain exchange rate maps in phantoms and healthy rat brains.

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