Abstract #3583

MR/optical image-guided liposomal drug delivery system for triple negative breast cancer

Sudath Hapuarachchige¹, Wenlian Zhu¹, Yoshinori Kato^1,2, Marina V. Backer³, Susanta Sarkar⁴, Joseph M Backer^1,3, and Dmitri Artemov^1,5

¹Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Life Science Tokyo Advanced Research Center (L-StaR), Hoshi University School of Pharmacy and Pharmaceutical Science, Tokyo, Japan, ³SibTech, Inc., Brookfield, CT, ⁴CadenzaMed LLC, Wayne, PA, ⁵Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Noninvasive image-guided drug delivery is important in cancer drug development, and allows visualizing the delivery and predicting the outcome. In this study, the delivery and therapeutic effects of liposomes targeted to tumor vasculature was researched. Intravital microscopy and MRI were used for tracking the drug delivery and therapeutic effects were monitored in MDA-MB-231 mouse tumor model. Our experimental results suggest that targeting liposomes to VEGF receptors (VEGFRs) expressed on tumor endothelium, may inhibit EPR-mediated extravasation and accumulation of VEGFR-targeted liposomes.

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