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Abstract #3583

MR/optical image-guided liposomal drug delivery system for triple negative breast cancer

Sudath Hapuarachchige1, Wenlian Zhu1, Yoshinori Kato1,2, Marina V. Backer3, Susanta Sarkar4, Joseph M Backer1,3, and Dmitri Artemov1,5

1Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Life Science Tokyo Advanced Research Center (L-StaR), Hoshi University School of Pharmacy and Pharmaceutical Science, Tokyo, Japan, 3SibTech, Inc., Brookfield, CT, 4CadenzaMed LLC, Wayne, PA, 5Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Noninvasive image-guided drug delivery is important in cancer drug development, and allows visualizing the delivery and predicting the outcome. In this study, the delivery and therapeutic effects of liposomes targeted to tumor vasculature was researched. Intravital microscopy and MRI were used for tracking the drug delivery and therapeutic effects were monitored in MDA-MB-231 mouse tumor model. Our experimental results suggest that targeting liposomes to VEGF receptors (VEGFRs) expressed on tumor endothelium, may inhibit EPR-mediated extravasation and accumulation of VEGFR-targeted liposomes.

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