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Abstract #3582

A high-relaxivity extradomain-B fibronectin targeting gadolinium metallofullerene for cancer detection and differential diagnosis in molecular MRI

Zheng Han1 and Zheng-Rong Lu1

1Case Western Reserve University, Cleveland, OH, United States

Accurate cancer detection and characterization with MRI is hampered by the lack of safe and effective targeted MRI contrast agents. In this work, we have designed and synthesized a high-relaxivity targeted contrast agent by conjugating ZD2 peptide to hydroxylated Gd3N@C80. ZD2-Gd3N@C80 has a high T1 relaxivity of 76.4 mM-1s-1 per Gd at 1.5 Tesla and a small diameter of 1 nm on average. At a low dose of 5 ┬Ámol Gd/kg, ZD2-Gd3N@C80 is able to produce prominent contrast enhancement in the highly metastatic MDA-MB-231 triple-negative breast cancer model, but not in the estrogen-dependent MCF-7 tumors.

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