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Abstract #3581

MR Imaging of Nanoparticle Uptake and 3D Intra-tumoral Distribution in Orthotopic Xenograft Mouse Models of Neuroblastoma

Ketan B Ghaghada1, Saakshi Bhayana1, Igor Stupin1, Flavia Leao Barbosa1, Chandresh Patel1, Zbigniew Starosolski1, and Ananth Annapragada1

1Pediatric Radiology, Texas Children's Hospital, Houston, TX, United States

Heterogeneity in tumor vasculature gives rise to variability in vascular permeability, one of the consequences being non-uniform intra-tumoral uptake and distribution of nanoparticle-based chemotherapeutics. An imaging agent that can assess tumor vascular heterogeneity and monitor uptake and distribution of nanoparticles could be useful for guiding and monitoring nanoparticle-based chemotherapy. In this work, we demonstrate, in orthotopic mouse models of solid tumors, that a high T1 relaxivity liposomal-gadolinium contrast agent (liposomal-Gd) enables MR imaging of nanoparticle uptake and 3D intra-tumoral distribution at clinically-relevant MR field strength.

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