Our objective is to longitudinally monitor the nature and timing of immune cell guided inflammatory processes following multiple blasts in an animal model, in an effort to discern potential therapeutic windows. Blast, results in a heterogeneous whole-body inflammatory response that can be observed with a perfluorocarbon contrast agent and 19F MRI. A second closely timed blast increased the amount of fluorine signal in injured rats, which most likely represents increased macrophage accumulation. Despite having potent anti-inflammatory properties, we did not observe that a diet rich in omega-3 fatty acids has a significant impact on the inflammatory response to blast injuries.
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