A feedback system used in conjunction with a high concentration spin reservoir demonstrates an enhanced MRI signal from a molecular imaging target at low concentration. Enhanced images of a 10mM 19F FDG target obtained by a modified 3D Flash sequence are shown. Detectability curves reveal that for a 100ul voxel size, an imaging time of ~30 min is required to image 1mM 19F FDG with an SNR of 4.
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