Sodium MRI is a molecular imaging tool that may be sensitive to the impact of lymphatic impairment on tissue homeostasis, yet has not been evaluated in a clinical population with a lymphatic disorder. Lipedema is a lymphatic fat-disorder that is under-recognized due to a need for further advanced MR imaging to diagnosis and assess treatment efficacy of the condition. Here, we apply quantitative 3T sodium imaging for the first time in a lipedema cohort to quantify tissue sodium levels and found elevated sodium concentration in the skin and muscle of patients with lipedema compared to BMI- and age-matched controls.
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