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Abstract #3606

Acute afterload-imposed change in porcine cardiac metabolism imaged by hyperpolarized [1-13C]Pyruvate

Rasmus Stilling Tougaard1,2, Esben Søvsø Szocska Hansen2, Christoffer Laustsen2, Jakob Lindhardt2, Marie Schroeder2, Hans Erik Bøtker1, Won Yong Kim1,2, Henrik Wiggers1, and Hans Stødkilde-Jørgensen2

1Department of Cardiology - Research, Aarhus University Hospital, Aarhus N, Denmark, 2MR Research Centre, Aarhus University, Aarhus N, Denmark

Deranged metabolism is now considered a key causal factor in heart failure and has therefore gained considerable scientific interest. The novel technique hyperpolarized MR has emerged as a leading methodological candidate to study these derangements. We employed a clinically relevant, large animal model of angiotensin-II-mediated acute hypertension to study cardiac metabolism in the setting of elevated afterload using hyperpolarized [1-13C]Pyruvate MR. The method was able to detect acute increases in both anaerobic and aerobic cardiac metabolism, which, in the future could mean a useful way of monitoring a possible treatment response to afterload reduction by using hyperpolarized MR.

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