Meeting Banner
Abstract #3607

Hyperpolarized [1-13C]Pyruvate MRI identifies metabolic differences pertaining to the fasted and fed state in porcine cardiac metabolism

Rasmus Stilling Tougaard1,2, Esben Søvsø Szocska Hansen2, Christoffer Laustsen2, Thomas Stokholm Nørlinger2, Emmeli Mikkelsen2, Jakob Lindhardt2, Marie Schroeder2, Per Mose Nielsen2, Lotte Bonde Bertelsen2, Hans Erik Bøtker1, Won Yong Kim1,2, Henrik Wiggers1, and Hans Stødkilde-Jørgensen2

1Department of Cardiology - Research, Aarhus University Hospital, Aarhus N, Denmark, 2MR Research Centre, Aarhus University, Aarhus N, Denmark

Standardized large animal models for cardiac hyperpolarized MR metabolic studies are becoming increasingly important as translation into human trials progresses. We employed a porcine (n=17) model of fasting/feeding to study these two states and to examine normal feeding as a standardized model for increasing hyperpolarized [1-13C]Pyruvate signal in the heart. All metabolic ratios were higher in fed animals with no additional variance. This indicates the role of pyruvate uptake to be more important in pigs than in rodents, underlining the need for large animals in metabolic research, and also suggests feeding to be a feasible, standardized model for increasing signal.

This abstract and the presentation materials are available to members only; a login is required.

Join Here