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Abstract #3608

Fumarate to Malate Conversion in Infarcted Porcine Heart – a Pilot Study

Esben Søvsø Szocska Hansen1,2, Rasmus Stilling Tougaard1,3, Per Mose Nielsen1, Jakob Lindhardt1, Hans Stødkilde Jørgensen1, and Christoffer Laustsen1

1The MR Research Centre, Aarhus University, 8200, Denmark, 2Danish Diabetes Academy, Odense, Denmark, 3Department of Cardiology, Aarhus University Hospital, 8200, Denmark

Hyperpolarized MR may be a key tool for investigation cardiac metabolism and cardiac treatment response. [1,4-13C2]Fumarate is an emerging and interesting candidate for measuring and visualizing cardiac injury after ischemia. In this study we showed an initial step for imaging cardiac cell death in a large animal model with [1,4-13C2]malate. The [1,4-13C2]malate signal correlated well with increased 13C-lactate signal and 13C-alanine absence. Overall, this shows increased metabolism in the infarcted area and ongoing necrosis.

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