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Abstract #3609

Molecular Detection of Inflammation in a Macrophage Cell Model Using Hyperpolarized 13C-Pyruvate

Renuka Sriram1, Justin DeLos Santos1, Julia Nguyen1, Mark Van Criekinge1, Seth Vigneron2, John Kurhanewicz1, and John MacKenzie1

1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2University of California San Diego

Carbon-13 magnetic resonance with dynamic nuclear polarization is a potential molecular imaging strategy to detect and monitor inflammation. In this study we investigated hyperpolarized 13C-pyruvate and alterations in its conversion to 13C-lactate as an imaging biomarker for disease severity and monitoring treatment response in inflammatory disorders.

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