Abstract #3609

Molecular Detection of Inflammation in a Macrophage Cell Model Using Hyperpolarized 13C-Pyruvate

Renuka Sriram¹, Justin DeLos Santos¹, Julia Nguyen¹, Mark Van Criekinge¹, Seth Vigneron², John Kurhanewicz¹, and John MacKenzie¹

¹Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²University of California San Diego

Carbon-13 magnetic resonance with dynamic nuclear polarization is a potential molecular imaging strategy to detect and monitor inflammation. In this study we investigated hyperpolarized 13C-pyruvate and alterations in its conversion to 13C-lactate as an imaging biomarker for disease severity and monitoring treatment response in inflammatory disorders.

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