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Abstract #3613

Regional Analysis of Hyperpolarized Lactate-to-Pyruvate Ratio Can Improve Sensitivity to Monitor Progression of Acute Pulmonary inflammation

Mehrdad Pourfathi1, Hooman Hamedani1, Yi Xin1, Stephen Kadlecek1, Maurizio Cereda2, Harrilla Profka1, Ian Duncan1, Nicholas Drachman1, Sarmad Siddiqui1, Kai Ruppert1, Joe Naji1, and Rahim Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States

In this hyperpolarized pyruvate imaging study of acute lung injury, we assessed alterations of regional lactate-to-pyruvate ratio during the progression of lung inflammation caused by acid aspiration. The study shows that posterior lactate-to-pyruvate ratio changes more significantly after injury compared to the anterior ratio. This is consistent with the pattern observed with proton MRI. We report good correlation between increased lactate-to-pyruvate ratio due to inflammation and increased proton image intensity as a result of formation of edema, especially in the posterior regions.

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