In this hyperpolarized pyruvate imaging study of acute lung injury, we assessed alterations of regional lactate-to-pyruvate ratio during the progression of lung inflammation caused by acid aspiration. The study shows that posterior lactate-to-pyruvate ratio changes more significantly after injury compared to the anterior ratio. This is consistent with the pattern observed with proton MRI. We report good correlation between increased lactate-to-pyruvate ratio due to inflammation and increased proton image intensity as a result of formation of edema, especially in the posterior regions.
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