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Abstract #3614

Metabolic characterization of rat lung transplantation using HP [1-13C]-pyruvate MRI

Sarmad Siddiqui1, Mehrdad Pourfathi1, Andreas Habertheuer2, Yi Xin1, Harrilla Profka1, Hooman Hamedani1, Stephen Kadlecek1, Ali Naji2, Prashanth Vallabhajosyula2, and Rahim Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Surgery, University of Pennsylvania, Philadelphia, PA, United States

Orthotopic rat lung transplantation is a well-established animal model used for elucidating the mechanics of lung transplant surgery. However, most lung function assessment is conducted via invasive techniques. In this study, we demonstrated that hyperpolarized pyruvate MRI can be used to generate metabolic biomarkers that can be used for non-invasive lung function assessment after transplantation. In successful syngeneic lung transplants, the lactate-to-pyruvate ratio remains low in both lungs after transplant. However, in allogeneic or failed syngeneic lung transplantation, the native lung returns to baseline one week after surgery, whereas the transplanted lung shows a significant(~3-fold) increase in the lactate-to-pyruvate ratio.

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