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Abstract #3615

3D Whole-Brain Mapping of Cerebral Blood Flow using Velocity-Selective Pulse Trains: Evaluating Various Strategies for Background Suppression

Qin Qin1,2

1Johns Hopkins University, Baltimore, MD, United States, 2Kennedy Krieger Institute, Baltimore, MD, United States

Velocity-selective arterial spin labeling (VSASL) has only been realized with 2D multi-slice acquisition. ASL with 3D readout is preferred for clinical applications and background suppression technique is essential for successful implementation of segmented 3D ASL. In this study, various strategies for background suppression are evaluated for 3D VSASL which are labeled with conventional T2prep VS pulse train, and new Fourier transform based velocity-selective saturation and inversion pulse trains, respectively. The optimal 3D whole-brain VSASL protocol is compared with PCASL for mapping cerebral blood flow on normal volunteers at 3T.

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