Hadamard-encoded vessel-encoded pCASL is a vessel-selective ASL technique that enables SNR-efficient vascular territory mapping for perfusion MRI. For vessel-selective ASL-MRA, however, minimising the number of encodings is necessary to achieve clinically feasible scan times. The spatial modulation of inversion in ve-pCASL is gradual, which could potentially reduce SNR-efficiency and cause mislabeling of arteries when reducing the number of encodings. In this study, the modulation of ve-pCASL was optimized to achieve sharper inversion to avoid signal contamination of non-targeted arteries and achieve 4D-MRA with a minimal number of Hadamard-encodings.
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