Abstract #3618

In-vivo evaluation of pCASL labeling scheme and position

Marta Vidorreta^1,2, Li Zhao³, Sheila Shankar⁴, Daniel H Wolf⁴, David C Alsop³, and John A Detre^1,2

¹Neurology, University of Pennsylvania, Philadelphia, PA, United States, ²Radiology, University of Pennsylvania, Philadelphia, PA, United States, ³Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, MA, United States, ⁴Psychiatry, University of Pennsylvania, PA, United States

Despite recent consensus in the ASL community on pseudo-continuous ASL as preferred labeling method, several challenges still exist towards optimizing pCASL labeling efficiency in-vivo, including its sensitivity to vessel tortuosity and off-resonance effects. In this work, we assess the impact of labeling plane location and labeling scheme on the ASL perfusion signal.

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