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Abstract #3618

In-vivo evaluation of pCASL labeling scheme and position

Marta Vidorreta1,2, Li Zhao3, Sheila Shankar4, Daniel H Wolf4, David C Alsop3, and John A Detre1,2

1Neurology, University of Pennsylvania, Philadelphia, PA, United States, 2Radiology, University of Pennsylvania, Philadelphia, PA, United States, 3Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, MA, United States, 4Psychiatry, University of Pennsylvania, PA, United States

Despite recent consensus in the ASL community on pseudo-continuous ASL as preferred labeling method, several challenges still exist towards optimizing pCASL labeling efficiency in-vivo, including its sensitivity to vessel tortuosity and off-resonance effects. In this work, we assess the impact of labeling plane location and labeling scheme on the ASL perfusion signal.

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