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Abstract #3637

Assessment of Resting State Perfusion and Coherent Large-Scale Brain Networks in Healthy Aging Using Arterial Spin Labeling Perfusion MRI

Alvaro Galiano1, Reyes García de Eulate1, Marta Vidorreta2, Miriam Recio3, and María Fernández-Seara1,4

1Radiology, University of Navarra Hospital, Pamplona, Spain, 2Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, United States, 3Neurology, University of Navarra Hospital, Pamplona, Spain, 4Biomedical Engineering, TECNUN, University of Navarra, San Sebastian, Spain

Cognitive decline is associated with aging even in the absence of disease. In this study ASL perfusion fMRI was used to investigate changes in perfusion and resting state networks connectivity due to aging, by comparing two groups of healthy subjects (young and elderly). Results showed perfusion deficits in the elderly group, in association areas, related with advanced cognitive abilities. Disruptions in varios core RSNs were also detected. Assessment of perfusion and resting functional connectivity jointly could be a good predictor of cognitive decline and a good biomarker for treatments aiming to extend cognitive abilities.

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