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Abstract #3638

Trait Specificity of Regional Cerebral Blood Flow between Different Resting-State Conditions

Zhengjun Li1, Marta Vidorreta1, Daniel Wolf2, and John A. Detre1

1Dept. of Neurology, University of Pennsylvania, Philadelphia, PA, United States, 2Dept. of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States

We used latent state-trait theory to examine trait specificity of regional cerebral blood flow (CBF) acquired using arterial spin labeled (ASL) perfusion MRI in four different resting-state conditions (eyes-open, eyes-closed, fixation, and a low-level attention task (psychomotor vigilance task, PVT)). Most brain regions accepted the latent state-trait model. Fixation exhibited the lowest latent trait specificity, while PVT, eyes-open, and eyes-closed showed progressively higher trait specificity. We confirmed that ASL CBF shows trait-like properties, which are optimally fit using eyes-open or eyes-closed conditions.

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