The crucial role of iron for normal neurological function in human brain has been well recognized. The iron concentration evolution trajectories in human brain deep nucleus have been shown monotonously increased with aging. However, previous studies concern only on iron concentration. At the same time, atrophy occurs in healthy ageing brains. These two competing effects raise an interesting possibility that the total iron content in deep brain nuclei may decrease. Surprisingly, the iron content, investigated by QSM, in globus pallidus, substantia nigra and red nuclei appear to decrease after the iron content reaching a peak.
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