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Abstract #3657

Quantitative susceptibility mapping: phase images and microstructure

Lukas R Buschle1,2, Christian H Ziener1, Michael O Breckwoldt2, Artur Hahn2, Julia Bode3, Björn Tews3, Martin Bendszus2, Heinz-Peter Schlemmer1, and Felix T Kurz1,2

1E010 Radiology, German Cancer Research Center, Heidelberg, Germany, 2Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany, 3Schaller Research Group, University of Heidelberg and German Cancer Research Center, Heidelberg, Germany

In this work, the effect of inhomogeneous microstructure on quantitative susceptibility mapping (QSM) is simulated for typical microstructural geometries. The results suggest that the susceptibility of blood-filled capillaries can not be measured using quantitative susceptibility mapping due to the symmetry of the local Larmor frequency around a capillary. However, numerical simulations show that the concentration of spherically-shaped magnetic particles (contrast agents) is determinable with QSM. These results are therefore essential for a detailed analysis of quantitative susceptibility images.

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