In this work, the effect of inhomogeneous microstructure on quantitative susceptibility mapping (QSM) is simulated for typical microstructural geometries. The results suggest that the susceptibility of blood-filled capillaries can not be measured using quantitative susceptibility mapping due to the symmetry of the local Larmor frequency around a capillary. However, numerical simulations show that the concentration of spherically-shaped magnetic particles (contrast agents) is determinable with QSM. These results are therefore essential for a detailed analysis of quantitative susceptibility images.
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