Automatic Region of Interest (ROI) generation is useful for large clinical studies using Quantitative Susceptibility Mapping (QSM) as this allows mean susceptibility values for anatomical regions to be reported without manual intervention.
Several methods to generate ROIs are compared in this work. We found that methods based on T1 contrast showed little variation whether a typical magnitude image from a susceptibility protocol or a structural MPRAGE image was used. An additional method based on a QSM atlas showed greater variability in ROIs.
Mean susceptibility values for ROIs were shown to vary greatly depending on the method used to generate ROIs.