Abstract #3683

Ultrashort Echo Time Quantitative Susceptibility Mapping (UTE-QSM): Limitations in Quantifying High Iron Concentration

Xing Lu^1,2, Alexey Dimov³, Qun He¹, Yajun Ma¹, Yi Wang³, Eric Y Chang^1,4, and Jiang Du¹

¹Department of Radiology, University of California, San Diego, CA, United States, ²Institute of Electrical Engineering, Chinese Academy of Science, Beijing, People's Republic of China, ³Department of Radiology, Weill Cornell Medical College, New York, NY, United States, ⁴Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

Iron overload can affect not only the central nervous system, but the liver, pancreas, myocardium, endocrine glands, and musculoskeletal structures. A reliable quantitative method to detect and measure high concentration iron in vivo would be of great clinical utility. Ultrashort echo time (UTE) sequences have echo times (TE) 100-1000 times shorter than clinical sequences, and may detect signal from high iron concentration. In this study, we aimed to evaluate the capability of UTE-QSM sequence in quantifying high iron concentration with an Iron phantom study and the results show that UTE-QSM techniques can quantify high iron concentration up to 22 mM or higher.

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