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Abstract #3686

Investigation of Brain Tissue Fixation on Iron Concentration, Magnetic Susceptibility and Effective Transverse Relaxation Rate

Andreas Deistung1,2, Verena Endmayr3, Simon Hametner3, Max Prihoda4,5, Xiang Feng1, Hans Lassmann3, Jürgen Rainer Reichenbach1, Simon Daniel Robinson6, Evelin Haimburger4, Christian Menard7, Thomas Haider8, Hannes Traxler9, Siegfried Trattnig6, and Günther Grabner4,5,6

1Medical Physics Group, Institute for Diagnostic and Interventional Radiology, Jena University Hospital – Friedrich Schiller-University, Jena, Germany, 2Section of Experimental Neurology, Department of Neurology, Essen University Hospital, Essen, Germany, 3Center for Brain Research, Medical University of Vienna, Vienna, Austria, 4Department of Radiologic Technology, Carinthia University of Applied Sciences, Klagenfurt, Austria, 5Institute for Applied Research on Ageing, Carinthia University of Applied Sciences, Klagenfurt, Austria, 6High Field Magnetic Resonance Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 7Department of Medical Engineering, Carinthia University of Applied Sciences, Klagenfurt, Austria, 8University Clinic for Trauma Surgery, Medical University of Vienna, Vienna, Austria, 9Center of Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria

We investigated the effect of brain tissue fixation on iron concentration and on quantitative maps of the magnetic susceptibility and effective transverse relaxation rate (R2*). Both R2* and susceptibility distributions of unfixed and fixed tissue were found to be similar, indicating similar underlying proportions of iron across tissues. Quantitatively, however, severe decreases of iron concentration of 25% in putamen and about 15% in white matter were measured after tissue fixation. The iron concentration change due to tissue fixation was captured by R2* and susceptibility which needs to be considered when directly comparing experiments performed with unfixed and fixed brain tissue.

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