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Abstract #3687

Simultaneous multislice acquisition without trajectory modification for hyperpolarized 13C experiments

Angus Z. Lau1,2, Albert P. Chen3, Justin Y.C. Lau1,2, and Charles H. Cunningham1,2

1Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3GE Healthcare, Toronto, ON, Canada

Recently we proposed using simultaneous multislice (SMS) acceleration to improve spatial coverage in the hyperpolarized 13C experiment, and demonstrated that controlled aliasing improves conditioning of the inverse problem. For single-shot experiments this requires gradient modulation along z, which can be sensitive to gradient imperfections. Here, we show that inherent coil sensitivity variations can be sufficient for SMS acceleration in hyperpolarized 13C experiments, without additional readout gradient modification. Two-fold acceleration with a 8 cm slice gap can be obtained with less than 20% SNR loss. We anticipate that this strategy will enable multiple organ 13C imaging of in vivo metabolism.

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