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Abstract #3688

Slice Selective Adiabatic Refocusing Pulses for High Field, Pre-Clinical Hyperpolarized C-13 Imaging

Xucheng Zhu1, Jeremy W Gordon2, and Peder EZ Larson1,2

1Bioengineering, UCSF, Albany, CA, United States, 2Radiology & Biomedical Imaging, University of California - San Francisco, CA, United States

Due to limited transmit coil volume, refocusing pulses spoil magnetization located around the edge of the coil even with adiabatic pulses. This is a major problem for hyperpolarized 13C MRI, as this can destroy precious magnetization. To overcome this drawback, we propose to use a high bandwidth slice-selective adiabatic pulse to replace the original non-selective pulse. We designed and optimized the pulse via simulation. Then the slice-selective double spin echo sequence was tested on both phantom and in vivo studies.

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