Abstract #3689

Improved Off-Resonance Robustness for Spectral-Spatial Excitation and Echo-Planar Imaging of Hyperpolarized [1-13C]Pyruvate and Metabolites

Justin YC Lau^1,2, Benjamin J Geraghty^1,2, Yiping Gu¹, Albert P Chen³, and Charles H Cunningham^1,2

¹Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ²Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³GE Healthcare, Toronto, ON, Canada

An interleaved multi-echo imaging sequence is proposed to improve off-resonance robustness for spectral-spatial excitation and echo-planar imaging of hyperpolarized [1-¹³C]pyruvate. A non-iterative pointwise k-space signal decomposition approach for removing pyruvate hydrate contamination from lactate images is presented. Performance of the sequence and reconstruction pipeline was evaluated using an ethylene glycol phantom and a catalyzing enzyme system. Minimal signal loss and successful removal of pyruvate hydrate contamination were demonstrated in vivo for realistic cases of off-resonance.

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