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Abstract #3699

Overdiscrete Reconstruction for Signal Enhancement in Hyperpolarized 13C Spectroscopic Imaging

Eduardo Coello1,2, Esben S. Hansen3, Christoffer Laustsen3, Bjoern Menze1, Axel Haase1, and Rolf Schulte2

1Technische Universität München, Munich, Germany, 2GE Global Research, Munich, Germany, 3MR Research Centre, Aarhus University, Aarhus, Denmark

The overdiscrete reconstruction, originally proposed for 1H MR Spectroscopic Imaging (MRSI), is adapted and applied to hyperpolarized 13C MRSI. The method is demonstrated for in-vivo hyperpolarized [1-13C]-pyruvate scans of a pig’s kidneys using phase encoded 2D-MRS. Linewidth and spectral separation were improved in addition to a significant signal enhancement for low concentrated downstream metabolites such as lactate, alanine and pyruvate-hydrate.

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