Meeting Banner
Abstract #3700

Repeatability of quantitative hyperpolarized 13C MRSI measures of renal metabolism: impact of flow-sensitive gradients

Erin B Adamson1, Kai D Ludwig1, Benjamin L Cox1,2,3, and Sean B Fain1,4,5

1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2Morgridge Institute for Research, Madison, WI, United States, 3Laboratory for Optical and Computational Instrumentation, University of Wisconsin-Madison, Madison, WI, United States, 4Radiology, University of Wisconsin-Madison, Madison, WI, United States, 5Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States

Real-time quantification of in vivo metabolism with hyperpolarized 13C magnetic resonance spectroscopic imaging (MRSI) is currently limited by partial volume effects from intense vascular signal. Flow-sensitive, bipolar gradients are an attractive option for suppressing vascular signal due to their minimal influence on static spins. This work looks at the impact of incorporating bipolar gradients on the quantification and repeatability of hyperpolarized 13C MRSI metabolic measures of lactate-to-pyruvate area-under-the-curve ratios (AUCratio). The results suggest that incorporating bipolar gradients mitigates vascular partial voluming, increasing measured AUCratio, while reducing measurement repeatability, indicated by the larger repeatability coefficients.

This abstract and the presentation materials are available to members only; a login is required.

Join Here