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Abstract #3701

A Referenceless Workflow for Hyperpolarized 13C EPI

Jiazheng Wang1, Alan Wright1, Richard Hesketh1, De-en Hu1, and Kevin M Brindle1,2

1Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, 2Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

We have developed a workflow for hyperpolarized 13C EPI phase correction that requires no reference scan. The workflow provides ghost-free images on phantoms with large or tight fields of view and where there are multiple signal sources. Dynamic images acquired from hyperpolarized [1-13C]pyruvate and [1-13C]lactate in a tumor showed comparable image quality to those corrected using a separate 13C reference scan.

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